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Oxidation-labile linkers for controlled drug delivery
Aitor Carneiro1, Lourdes Santana2, Maria João Matos2
1CIQUP-IMS, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre 687, 4169-007 Porto, Portugal.
Bioorganic & Medicinal Chemistry Letters
|April 2, 2023
Summary
This review explores oxidation-labile linkers for targeted drug delivery in conditions like cancer and neurodegenerative diseases. These linkers enable controlled drug release in oxidative environments, enhancing therapeutic efficacy.
Area of Science:
- Chemical biology
- Drug discovery
- Bioconjugation
Background:
- Protein-drug and peptide-drug conjugates are key for targeted drug delivery, selectivity, and efficacy.
- Linker and payload selection is critical for in vivo stability and therapeutic action.
- Oxidative stress is a significant factor in neurodegenerative diseases and some cancers.
Purpose of the Study:
- To review relevant publications on oxidation-labile linkers.
- To highlight the application of these linkers in targeted drug delivery for diseases involving oxidative stress.
Main Methods:
- Literature review of scientific publications.
- Focus on bioconjugates and linker chemistry.
- Analysis of drug release mechanisms in oxidative environments.
Main Results:
- Oxidation-labile linkers can be designed for controlled drug release.
- These linkers are particularly relevant for treating conditions with high oxidative stress.
- The review consolidates key findings on the design and application of such linkers.
Conclusions:
- Oxidation-labile linkers represent an innovative strategy in targeted drug delivery.
- Their application holds promise for treating neurodegenerative diseases and cancers.
- Further research into these linkers can optimize therapeutic outcomes.
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