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Bioactive Vitamins and Epigenetic Modifications in Diabetes: A Perspective
Mihnea-Alexandru Găman1,2, Elena-Codruța Cozma3,4, Bahadar S Srichawla5
1Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii Sanitari Boulevard, Bucharest 050474, Romania.
Current Diabetes Reviews
|April 3, 2023
Summary
Dietary bioactive vitamins impact epigenetic changes in diabetes. These vitamins influence gene expression and DNA methylation, crucial for managing this metabolic disease.
Area of Science:
- Metabolic disease research
- Epigenetics and nutrition
Background:
- Diabetes mellitus is linked to complex epigenetic alterations.
- Dietary factors, including micronutrients and macronutrients, can disrupt metabolic homeostasis.
- Bioactive vitamins play a role in cellular processes relevant to epigenetics.
Purpose of the Study:
- To explore the significance of bioactive vitamins in diabetes-related epigenetic modifications.
- To provide a perspective on how vitamins influence epigenetic mechanisms in the context of diabetes.
Main Methods:
- Literature review and perspective synthesis.
- Analysis of vitamin roles in gene expression and DNA methylation.
- Examination of vitamin coenzyme and cofactor functions in methyl group metabolism.
Main Results:
- Bioactive vitamins can modulate epigenetic pathways.
- Vitamins are involved in regulating gene expression.
- Vitamins act as cofactors in DNA and histone methylation processes.
Conclusions:
- Bioactive vitamins are relevant to epigenetic changes observed in diabetes.
- Understanding vitamin-epigenetic interactions may offer new insights into diabetes management.
- Dietary interventions focusing on bioactive vitamins could influence diabetes epigenetics.
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