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Stress Hyperglycemia Ratio Is Associated With High Thrombus Burden in Patients With Acute Coronary Syndrome

Engin Algül1, Nail Burak Özbeyaz2, Haluk Furkan Şahan1

  • 1Department of Cardiology, University of Health Sciences, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.

Angiology
|April 3, 2023
PubMed

Insights

The stress hyperglycemia ratio (SHR) effectively predicts high thrombus burden in acute coronary syndrome (ACS) patients. This indicator shows greater sensitivity than admission glucose levels for assessing prognosis in ACS.

Area of Science:

  • Cardiology
  • Endocrinology
  • Medical Diagnostics

Background:

  • Admission blood glucose levels have limitations in predicting prognosis and thrombus burden in acute coronary syndrome (ACS).
  • Stress hyperglycemia is associated with increased thrombus burden in ACS patients.
  • The stress hyperglycemia ratio (SHR) is an emerging indicator of stress hyperglycemia.

Purpose of the Study:

  • To evaluate the predictive value of the stress hyperglycemia ratio (SHR) for thrombus burden in patients with ACS.
  • To compare the sensitivity of SHR versus admission glucose levels in predicting high thrombus burden.

Main Methods:

  • A cross-sectional study involving 1222 patients with ACS.
  • Coronary thrombus burden was classified as high or low.
  • SHR was calculated using admission serum glucose and HbA1c-derived estimated average glucose.

Main Results:

  • SHR was significantly higher in patients with high thrombus burden (HTB) compared to low thrombus burden.
  • Univariate analysis identified SHR as a predictor of HTB (OR 1.547, P < .001).
  • Multivariate analysis confirmed SHR as an independent risk factor for HTB (OR 1.328, P = .001).
  • SHR demonstrated higher sensitivity in predicting thrombus burden than admission glucose levels.

Conclusions:

  • The stress hyperglycemia ratio (SHR) is a valuable predictor of high thrombus burden in ACS patients.
  • SHR offers improved sensitivity over admission glucose levels for assessing thrombus burden in ACS.
  • SHR can aid in risk stratification and prognosis assessment for ACS patients.

Keywords:
acute coronary syndromestress hyperglycemia ratiothrombus

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