Related Experiment Video

Updated: Aug 4, 2025

Preparation of Mitochondria from Ovarian Cancer Tissues and Control Ovarian Tissues for Quantitative Proteomics Analysis
11:51

Preparation of Mitochondria from Ovarian Cancer Tissues and Control Ovarian Tissues for Quantitative Proteomics Analysis

Published on: November 18, 2019

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Potential Therapeutic Targets in Ovarian Cancer: Autophagy and Metabolism

Misung Park1,2, Soohyun Choe1, Miyoung Shin3

  • 1Department of Medical and Biological Sciences, The Catholic University of Korea, 14662 Bucheon, Republic of Korea.

Frontiers in Bioscience (Landmark Edition)
|April 3, 2023
PubMed

Insights

Ovarian cancer survival can be improved by targeting autophagy and metabolism. Understanding these processes offers new therapeutic strategies for this deadly disease.

Area of Science:

  • Oncology
  • Cell Biology
  • Biochemistry

Background:

  • Ovarian cancer (OC) presents high mortality due to late diagnosis and chemoresistance.
  • Autophagy and cellular metabolism are crucial in cancer progression and are emerging therapeutic targets.
  • Autophagy's role in cancer varies with stage and type, necessitating targeted control.

Purpose of the Study:

  • To review the roles of autophagy and metabolism in ovarian cancer.
  • To highlight therapeutic strategies targeting these fundamental cellular processes in OC.

Main Methods:

  • Literature review of studies on autophagy, metabolism, and ovarian cancer.
  • Analysis of the interplay between autophagy, metabolism, and immune response in OC.
  • Discussion of therapeutic interventions targeting autophagy and metabolic pathways.

Main Results:

  • Autophagy and metabolism are intricately linked, influencing OC development and progression.
  • Metabolites and metabolic genes modulate autophagy, impacting the tumor microenvironment and immune evasion.
  • Targeting autophagy and metabolic reprogramming shows promise for novel OC treatments.

Conclusions:

  • Autophagy and metabolism are key players in ovarian cancer pathogenesis.
  • Manipulating these pathways offers potential for effective ovarian cancer therapies.
  • Further research into targeting autophagy and metabolism is warranted for improved patient outcomes.
Keywords:
autophagycancer therapeuticsmetabolismmetabolitesovarian cancer

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