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Changes in the subepithelial mesenchymal cell process meshwork in developing facial prominences in mouse embryos
Journal of Craniofacial Genetics and Developmental Biology
|January 1, 1986
Summary
The study reveals that the subepithelial mesenchymal cell process meshwork (CPM) in the medial nasal prominence (MNP) significantly increases during facial prominence fusion. This CPM density change is crucial for upper lip and palate formation.
Area of Science:
- Developmental biology
- Craniofacial development
- Cell biology
Background:
- Facial prominence fusion is essential for forming the upper lip and primary palate.
- The role of the subepithelial mesenchymal cell process meshwork (CPM) in this process is not fully understood.
Purpose of the Study:
- To investigate the temporal and spatial changes in the CPM during the fusion of medial (MNP) and lateral nasal prominences (LNP) in mouse embryos.
- To elucidate the relationship between CPM dynamics, mesenchymal cell density, and epithelial morphology during facial fusion.
Main Methods:
- Light and scanning electron microscopy were used to examine CPM and cellular changes.
- Analysis focused on normally developing mouse embryos during MNP and LNP fusion.
Main Results:
- CPM density significantly increased in the MNP's prospective fusion area as epithelial surfaces approached, peaking before contact.
- CPM density changes were minimal in the LNP.
- Increased CPM density correlated with increased mesenchymal cell body density in the MNP.
- The MNP exhibited more fusion-associated epithelial changes than the LNP.
Conclusions:
- Increased CPM density in the MNP is linked to facial prominence growth and epithelial remodeling during fusion.
- The CPM plays a critical role in epithelial-mesenchymal interactions during upper lip and primary palate development.