Extranodal Diffuse Large B-Cell Lymphoma (DLBCL) Presenting as Diffuse Joint Pain: A Diagnostic Dilemma

Area of Science:

• Oncology
• Hematology
• Pediatric Oncology

Background:

• Diffuse Large B-Cell Lymphoma (DLBCL) is the most common subtype of Non-Hodgkin Lymphoma (NHL).
• Bone involvement in DLBCL is uncommon, often presenting late with symptoms like pain or fractures.
• Pediatric cases of primary bone DLBCL are exceptionally rare.

Observation:

• A 15-year-old male presented with joint pain, swelling, and B symptoms.
• Radiological imaging showed multiple lytic bone lesions and soft tissue collections.
• Initial presentation suggested an infectious process, creating a diagnostic challenge.

Findings:

• Biopsy confirmed the diagnosis of DLBCL involving bone and soft tissues.
• The case illustrates a rare presentation of pediatric DLBCL.
• The findings underscore the importance of histopathological examination for definitive diagnosis.

Implications:

• Early and accurate diagnosis of bone DLBCL is crucial for timely treatment initiation.
• This case expands the understanding of rare DLBCL presentations in pediatric patients.
• Highlights the diagnostic challenges in differentiating bone DLBCL from other conditions like infection.