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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Published on: June 16, 2014

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Association of the Systemic Immune-Inflammation Index with Outcomes in Acute Coronary Syndrome Patients with Chronic

Sanling Shi1, Shuting Kong1, Weicheng Ni1

  • 1Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People's Republic of China.

Journal of Inflammation Research
|April 3, 2023
PubMed

Insights

The systemic immune-inflammation index (SII) predicts adverse cardiovascular outcomes in patients with acute coronary syndrome and chronic kidney disease. An elevated SII indicates a higher risk of major adverse cardiovascular events.

Area of Science:

  • Cardiology
  • Nephrology
  • Immunology

Background:

  • The systemic immune-inflammation index (SII) is a novel marker reflecting immune and inflammatory status.
  • SII has been linked to poor prognosis in cardiovascular diseases.

Purpose of the Study:

  • To investigate the association between SII and major adverse cardiovascular events (MACEs) in patients with acute coronary syndrome (ACS) and chronic kidney disease (CKD).

Main Methods:

  • 744 patients with ACS and CKD were categorized into high and low SII groups.
  • Follow-up for MACEs (cardiovascular death, myocardial infarction, stroke) over a median of 2.5 years.
  • Statistical analyses included ROC curve, Kaplan-Meier, and Cox regression.

Main Results:

  • An SII cutoff of 1159.84×10^9/L best predicted MACEs.
  • High SII group had significantly higher MACE rates (38.8% vs 12.8%) and risk.
  • Elevated SII was an independent predictor of MACEs (aHR: 1.865, 95% CI: 1.197-2.907).

Conclusions:

  • Elevated SII is associated with adverse cardiovascular outcomes in ACS patients with CKD.
  • SII may serve as a valuable prognostic predictor in this patient population.
  • Further research is warranted to validate these findings.
Abstract

Keywords:
acute coronary syndromechronic kidney diseaseinflammationprognosis

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