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Association of microRNA gene polymorphisms with recurrent spontaneous abortion: An updated meta‑analysis
Xueqin Wang1, Yan Xing1, Yongyong Wang1
1Department of Reproductive Medicine, Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China.
Abstract:
Numerous studies have reported single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) associated with unexplained recurrent spontaneous abortion (URSA). The present study aimed to conduct an updated meta-analysis to confirm a pooled effect size of the association between miRNA SNPs and URSA. The relevant literature was searched on PubMed, EMBASE, Web of Science and Cochrane Library before July 2022 to identify case-control studies. The pooled odds ratio and confidence intervals at 95% of the eligible studies were extracted and evaluated under five genetic models. A total of 18 studies involving 3,850 cases and 4,312 controls were included. miR499a rs3746444 A>G, miR-149 rs2292832 T>C, miR-125a rs41275794 G>A and miR-10a rs3809783 A>T may enhance the risk of recurrent spontaneous abortion (RSA) under various genetic models. Although no separate association was found between the miR-125a rs12976445 C>T and miR-27a rs895819 A>G polymorphisms and RSA, statistical significance was found in certain ethnic groups only. The current analysis suggests a high significance of an up-to-date meta-analysis for screening out and preventing URSA among high-risk women by testing miRNA SNPs and RSA susceptibility.
Insights
Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) are linked to unexplained recurrent spontaneous abortion (URSA). This meta-analysis confirms specific miRNA SNPs increase URSA risk, aiding in screening and prevention for high-risk women.
Area of Science:
- Genetics
- Reproductive Medicine
- Molecular Biology
Background:
- Recurrent spontaneous abortion (RSA) is a complex condition with various contributing factors.
- Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) have been implicated in unexplained recurrent spontaneous abortion (URSA).
- Previous studies suggest associations, but an updated comprehensive analysis is needed.
Purpose of the Study:
- To conduct an updated meta-analysis evaluating the association between miRNA SNPs and URSA.
- To determine the pooled effect size of miRNA SNPs in relation to URSA risk.
- To identify specific miRNA SNPs that may serve as biomarkers for URSA susceptibility.
Main Methods:
- A systematic literature search was performed on PubMed, EMBASE, Web of Science, and Cochrane Library up to July 2022.
- Eligible case-control studies were included, extracting data on miRNA SNPs and URSA.
- Pooled odds ratios and 95% confidence intervals were calculated under five genetic models.
Main Results:
- Eighteen studies with 3,850 cases and 4,312 controls were analyzed.
- Specific miRNA SNPs, including miR499a rs3746444 A>G, miR-149 rs2292832 T>C, miR-125a rs41275794 G>A, and miR-10a rs3809783 A>T, were associated with increased URSA risk.
- Other SNPs showed ethnic-specific associations or no significant overall link to RSA.
Conclusions:
- Certain miRNA SNPs significantly enhance the risk of URSA.
- This meta-analysis highlights the importance of miRNA SNPs in URSA susceptibility.
- Testing miRNA SNPs could aid in screening and prevention strategies for URSA in high-risk populations.
