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Updated: Aug 4, 2025

Author Spotlight: Advancing VRL Diagnosis Using Cell-Free DNA Extraction from Vitreous Humor
Published on: January 12, 2024
Vitreoretinal Lymphoma as the Initial Presentation of a Breast Diffuse Large B-cell Lymphoma
Cole A Martin1, Joan H Admirand1, Shelley Day Ghafoori1,2
1University of Texas at Austin Dell Medical School, Austin, TX, USA.
Purpose:
We report a case of vitreoretinal lymphoma as the initial presentation of diffuse large B-cell lymphoma of the breast.
Methods:
A case report is presented.
Results:
A 72-year-old woman was referred for evaluation of vitritis in both eyes. Diagnostic vitrectomy and pathology workup demonstrated atypical lymphoid cells consistent with the presence of diffuse large B-cell lymphoma. Brain magnetic resonance imaging and lumbar puncture findings were negative for central nervous system lymphoma. Positron emission tomography/computed tomography imaging showed a mass in the left breast, and breast biopsy confirmed aggressive B-cell lymphoma.
Conclusions:
When vitreoretinal lymphoma is diagnosed, it is important to evaluate for other forms of systemic lymphoma in addition to central nervous system lymphoma.
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