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Menthol: An underestimated anticancer agent.

Yijia Zhao1, Huafeng Pan2, Wei Liu3

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|April 3, 2023
PubMed
Summary
This summary is machine-generated.

Menthol exhibits significant anticancer activity by inducing apoptosis and cell cycle arrest in various cancer cells. Further research is needed to fully elucidate its mechanisms for potential clinical application as a novel anticancer agent.

Keywords:
anticancerfuture directionmentholmolecular mechanismnatural product

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Area of Science:

  • Natural Products Chemistry
  • Pharmacology
  • Oncology

Background:

  • Menthol, a natural compound, demonstrates emerging anticancer properties.
  • It shows promise for treating various solid tumors.

Purpose of the Study:

  • To review the anticancer activity of menthol.
  • To explore the underlying mechanisms of menthol's antitumor effects.

Main Methods:

  • Literature review of studies from PubMed, EMBASE, Web of Science, Ovid, ScienceDirect, and China National Knowledge Infrastructure.
  • Analysis of menthol's anticancer mechanisms.

Main Results:

  • Menthol possesses a favorable safety profile.
  • It inhibits cancer cells via multiple pathways including apoptosis induction, cell cycle arrest, tubulin polymerization disruption, and angiogenesis inhibition.
  • Menthol demonstrates efficacy against diverse cancer types.

Conclusions:

  • Menthol displays significant anticancer potential through various mechanisms.
  • Further investigation is required to fully understand its antitumor effects and clinical applications.
  • Menthol and its derivatives warrant continued research for novel anticancer therapies.