Related Experiment Video
Updated: Aug 4, 2025

Intravitreal Injections in the Ovine Eye
Published on: July 5, 2022
Bietti crystalline dystrophy complicated by choroidal neovascularization treated with a single dose of aflibercept
Merve Ozbek1, Seren Pehlivanoglu1, Halil Ozgur Artunay1
1Department of Ophthalmology, Beyoglu Eye Training and Research Hospital, Istanbul, Turkey.
Abstract:
Bietti crystalline dystrophy is a rare hereditary autosomal recessive disease that causes photoreceptor loss secondary to degeneration of retinal pigment epithelium due to intracellular retinal pigment epithelial crystalline deposits and abnormal lipid metabolism. We aimed to present a case of choroidal neovascular membrane secondary to Bietti crystalline dystrophy diagnosed with multimodal imaging and treated with an intravitreal injection of aflibercept. A single dose of aflibercept injection might be effective due to its higher affinity for vascular endothelial growth factor (VEGF) in comparison with other anti-VEGFs. It might be a treatment alternative that can be considered in the choroidal neovascular membrane due to uncommon etiologies.
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