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Reticular corneal epithelial edema with topical netarsudil.

Dipali P Parmar¹, Pradnya K Bhole¹, Pawan V Garde¹

¹Department of Ophthalmology, M and J Institute of Ophthalmology (Government Eye Hospital), B. J. Medical College, Ahmedabad, Gujarat, India.

Oman Journal of Ophthalmology

|April 3, 2023

Summary

This summary is machine-generated.

Rho-associated kinase (ROCK) inhibitors, like netarsudil, can cause reticular epithelial edema (REE) in some patients. This side effect typically resolves upon discontinuation of the ROCK inhibitor therapy.

Keywords:

Netarsudil (0.02%) eye drop ROCK inhibitor reticular epithelial edema

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Area of Science:

Ophthalmology
Corneal Disease
Pharmacology

Background:

Rho-associated kinase (ROCK) inhibitors are used for corneal endothelial dysfunction, generally with few side effects.
Netarsudil 0.02% is a ROCK inhibitor used in ophthalmic treatments.

Observation:

Reticular epithelial edema (REE) was observed in four patients undergoing treatment with netarsudil.
These cases involved corneal transplants (3) and post-cataract extraction (1).

Findings:

REE developed variably in all observed cases.
Discontinuation of netarsudil led to REE clearance in three patients.
One patient continued netarsudil with REE not affecting the visual axis.

Implications:

ROCK inhibitor therapy, specifically netarsudil, may induce REE in certain ophthalmic conditions.
Monitoring for and managing REE is important during ROCK inhibitor treatment.
Partial stromal edema clearance suggests potential benefits alongside observed side effects.