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Related Experiment Video

Updated: Aug 4, 2025

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

Topical cyclosporine A and interferon alpha-2b as adjuvants to surgery to decrease pterygium recurrence.

Usha K Raina¹, Banu Pavitra¹, Shruti Bhattacharya¹

¹Department of Ophthalmology, Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India.

Oman Journal of Ophthalmology

|April 3, 2023

Summary

This summary is machine-generated.

Topical cyclosporine A (CsA) and interferon (IFN) alpha-2b are effective treatments to prevent pterygium recurrence after surgery. Both medications showed significant visual acuity improvement with minimal complications.

Keywords:

Cyclosporine interferon limbal conjunctival autograft pterygium

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Area of Science:

Ophthalmology
Surgical Innovation
Medical Treatments

Background:

Pterygium is a prevalent eye condition in India.
Limbal conjunctival autograft transplantation (LCAT) is the standard surgical treatment.
LCAT has a recurrence rate of up to 18%.

Purpose of the Study:

To evaluate the efficacy of topical cyclosporine A (CsA) and interferon (IFN) alpha-2b.
To compare these agents in preventing postoperative pterygium recurrence.
To assess the safety profiles of CsA and IFN alpha-2b.

Main Methods:

A randomized trial involving 40 patients with primary pterygium.
Patients underwent LCAT and were assigned to topical CsA or IFN alpha-2b postoperatively for 3 months.
Outcomes measured included visual acuity, recurrence rates, and complications.

Main Results:

Both CsA and IFN alpha-2b significantly improved best-corrected visual acuity (BCVA) post-surgery (P < 0.0001).
Pterygium recurrence was low: 2 cases in the CsA group and 1 in the IFN alpha-2b group.
No significant postoperative complications were reported in either treatment group.

Conclusions:

Topical CsA and IFN alpha-2b serve as effective adjuvant therapies.
These agents aid in preventing pterygium recurrence following LCAT.
The study highlights newer options for managing postoperative pterygium.