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Characteristics of Central Retinal Vein Occlusion in African Americans

Sieh Yean Kiew1, George N Thomas2, Akshay S Thomas3

  • 1Singapore National Eye Centre, Singapore.

Journal of Vitreoretinal Diseases
|April 3, 2023
PubMed

Insights

African Americans with central retinal vein occlusion (CRVO) experienced worse presenting vision and more risk factors. While final vision was similar, they faced a higher treatment burden and increased risk of complications.

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Public Health

Background:

  • Central Retinal Vein Occlusion (CRVO) is a significant cause of vision loss.
  • Understanding racial disparities in CRVO is crucial for equitable healthcare.
  • Previous research has not fully elucidated differences in CRVO characteristics and outcomes among racial groups.

Purpose of the Study:

  • To investigate if the clinical presentation and course of central retinal vein occlusion (CRVO) differ between African American patients and other racial groups.
  • To identify potential disparities in risk factors, treatment, and outcomes for CRVO in African Americans.

Main Methods:

  • A retrospective cohort study was conducted at Duke Eye Center.
  • Consecutive patients diagnosed with CRVO were analyzed based on patient-reported race.
  • Presenting characteristics, examination findings, treatment, and outcomes were compared across racial groups.

Main Results:

  • African American patients with CRVO were older and had higher rates of hypertension, diabetes, and open-angle glaucoma.
  • Presenting visual acuity was significantly worse in African American patients.
  • Although final visual acuity did not differ, African Americans experienced higher rates of neovascular sequelae and a greater treatment burden in the first year.

Conclusions:

  • African Americans with CRVO present with more severe visual impairment and greater systemic/ocular risk factors.
  • Treatment-naive African Americans with CRVO incurred a higher treatment burden within the first year.
  • These findings highlight potential disparities in CRVO management and outcomes that warrant further investigation.
Abstract

Keywords:
African Americanantivascular endothelial growth factor (anti-VEGF)central retinal vein occlusionpanretinal photocoagulation

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