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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
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Cryptococcal Meningitis Presenting as Endophthalmitis in an Otherwise Asymptomatic Patient
Travis J Peck1, Michael J Ammar1,2, James P Dunn1,2
1Department of Ophthalmology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
Journal of Vitreoretinal Diseases
|April 3, 2023
Summary
Cryptococcal endophthalmitis can be the first sign of a widespread infection. Prompt diagnosis and treatment are crucial, as this condition may indicate meningitis, even without typical symptoms.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Mycology
Background:
- Cryptococcus neoformans commonly affects the central nervous system, potentially causing fatal meningitis.
- Cryptococcal endophthalmitis is a rare ocular manifestation, usually associated with disseminated disease.
Observation:
- A 66-year-old immunocompromised patient presented with blurry vision and was diagnosed with cryptococcal endophthalmitis.
- The patient had an underlying bloodstream and central nervous system infection.
Findings:
- Intravenous and intravitreal antifungal treatment was administered.
- A significant subretinal mass lesion persisted despite treatment.
Implications:
- Cryptococcal endophthalmitis can be the initial clinical presentation of disseminated cryptococcosis.
- Positive vitreous cultures for Cryptococcus necessitate a presumption of meningitis, irrespective of symptoms.
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