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Assessment of Kidney Function in Mouse Models of Glomerular Disease
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Obesity-related glomerulopathy in children: connecting pathophysiology to clinical care

Guneive Mangat1, Nikhil Nair2, Oren Barat3

  • 1Department of Nephrology, Akron Nephrology Associates/Cleveland Clinic Akron General Medical Center, Akron, OH, USA.

Clinical Kidney Journal
|April 3, 2023
PubMed

Insights

Obesity-related glomerulopathy (ORG) is a kidney disease linked to obesity, primarily caused by podocyte damage. Key treatments involve weight loss and reducing proteinuria through lifestyle changes, medication, or surgery.

Area of Science:

  • Nephrology
  • Endocrinology
  • Public Health

Background:

  • Obesity is a global pandemic linked to numerous comorbidities.
  • Obesity-related glomerulopathy (ORG) is an emerging kidney disease associated with obesity.
  • ORG is characterized by podocyte damage, with contributing factors including RAAS activation, hyperinsulinemia, and lipid deposition.

Purpose of the Study:

  • To review the pathogenesis, clinical features, and treatment of obesity-related glomerulopathy (ORG).
  • To highlight the importance of addressing childhood obesity for primary prevention of ORG.
  • To discuss established and novel therapeutic strategies for ORG.

Main Methods:

  • Literature review of obesity-related glomerulopathy (ORG).
  • Analysis of current understanding of ORG pathophysiology.
  • Examination of treatment modalities for ORG.

Main Results:

  • Podocyte damage is the primary cause of ORG.
  • Weight loss and proteinuria reduction are crucial for managing ORG.
  • Lifestyle modification, pharmacotherapy, and surgery are primary treatment approaches.

Conclusions:

  • Understanding ORG pathophysiology is advancing.
  • Effective management of ORG requires a multi-faceted approach.
  • Preventing childhood obesity is essential for long-term ORG reduction.

Keywords:
ORGchildrenobesityobesity-related glomerulopathy

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