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Eosinophilic panniculitis: a clinicopathologic study.

R K Winkelmann, E Frigas

    Journal of Cutaneous Pathology
    |February 1, 1986
    PubMed
    Summary
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    Eosinophilic panniculitis presents diverse systemic and localized diseases, including Wells syndrome and vasculitis. This skin finding can indicate various conditions, from insect bites to lymphoma.

    Area of Science:

    • Dermatology
    • Pathology
    • Internal Medicine

    Background:

    • Eosinophilic panniculitis is a histopathological finding characterized by eosinophilic infiltration of subcutaneous fat.
    • Its clinical significance can range from localized reactions to indicators of systemic disease.

    Purpose of the Study:

    • To investigate the diverse clinical presentations and associated systemic conditions in patients with biopsy-proven eosinophilic panniculitis.

    Main Methods:

    • Retrospective analysis of 18 patients diagnosed with eosinophilic panniculitis via biopsy.
    • Review of clinical data, associated diseases, and histopathological findings.

    Main Results:

    • Diverse systemic associations were observed, including psychiatric illness (6), atopy (5), malignancies (5), and immune complex vasculitis (4).

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  • Skin lesions presented varied morphologies, always with a subcutaneous nodular component.
  • Eosinophilic panniculitis was associated with localized causes (e.g., insect bites, injection sites) and systemic diseases (e.g., lymphoma, immune reactive conditions).

    • Conclusions:

    • Eosinophilic panniculitis is a non-specific finding with a broad spectrum of associated conditions.
    • It can represent localized processes or serve as a marker for significant systemic diseases, necessitating thorough investigation.