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Rapid, Spontaneous Resolution of Prominent Subretinal Infiltrate in Vitreoretinal Lymphoma
Dan Gong1, Mary E Aronow1, Dean Eliott1
1Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Journal of Vitreoretinal Diseases
|April 3, 2023
Summary
Vitreoretinal lymphoma can manifest as transient subretinal infiltrates. This case report details spontaneous resolution of a large peripapillary infiltrate without treatment.
Area of Science:
- Ophthalmology
- Hematology
- Oncology
Background:
- Vitreoretinal lymphoma (VRL) is a rare intraocular malignancy.
- Diagnosis can be challenging due to varied presentations.
Observation:
- A 65-year-old woman presented with a large, peripapillary subretinal infiltrate in her left eye.
- Diagnostic vitrectomy revealed atypical lymphocytes with a positive MYD88 mutation.
Findings:
- The subretinal infiltrate showed rapid, spontaneous resolution prior to and continuing after surgery.
- No systemic or local ocular therapy was initiated for the infiltrate.
Implications:
- This case suggests that some subretinal infiltrates in VRL may be transient and resolve spontaneously.
- Highlights the importance of considering spontaneous resolution in the management of VRL ocular manifestations.
