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Updated: Aug 13, 2026
Experimental Models for Study of Retinal Pigment Epithelial Physiology and Pathophysiology
Published on: November 6, 2010
Fibroblast Growth Factor Receptor Inhibitor-Associated Multifocal Serous Retinal Detachments: A Case Report
Diana H Kim1, Tian Xia1, Peter Bracha1
1Department of Ophthalmology, Scheie Eye Institute, Penn Presbyterian Medical Center, Philadelphia, PA, USA.
Purpose:
This report aims to describe a case of bilateral, multifocal neurosensory retinal detachments that developed during erdafitinib therapy for metastatic urothelial carcinoma.
Methods:
A case report with color fundus imaging and spectral-domain optical coherence tomography imaging is presented.
Results:
A 50-year-old man with metastatic urothelial carcinoma had an unremarkable baseline ophthalmic examination prior to starting erdafitinib. At 3-month follow up, an examination revealed bilateral, multifocal retinal detachments. Because the patient was asymptomatic and erdafitinib was the only drug to which his tumor had responded, he was kept on the medication with close ophthalmic monitoring.
Conclusions:
Erdafitinib, a fibroblast growth factor receptor inhibitor, can cause bilateral, multifocal retinal detachments. Continuation of erdafitinib may be considered in patients without significant visual impairment when the overall benefit of the medication appears to outweigh the risks.
