Carcinoma in situ of the glans penis and distal urethra

A case is presented of erythroplasia of Queyrat involving the distal glans penis surrounding the urethral meatus. Therapy with topical 5-fluorouracil was followed by recurrence within 14 months. Treatment by excision utilizing the Mohs technique demonstrated carcinoma in situ of over 5 cm of the distal urethra. Plastic surgical reconstruction produced a cosmetically and functionally normal penis.