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Correlation analysis between jejunum metabolites and immune function in Saba and Landrace piglets
Yang He1, Yongxiang Li1, Yangsu Pan1
1Yunnan Provincial Key Laboratory of Animal Nutrition and Feed Science, Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, China.
Frontiers in Veterinary Science
|April 3, 2023
Summary
Saba pigs exhibit enhanced jejunal immune function and mucosal barrier integrity compared to Landrace pigs. This is linked to higher levels of taurodeoxycholic acid (TDCA), a key metabolite regulating gut health.
Area of Science:
- Animal Science
- Immunology
- Metabolomics
Background:
- Intestinal mucosa immune function is vital for host health.
- Jejunal chyme metabolites influence immune homeostasis.
- Limited research exists on jejunal metabolites in Saba (SB) pigs.
Purpose of the Study:
- Compare jejunal immunophenotypes and metabolites between SB and Landrace (LA) piglets.
- Investigate the role of metabolites in SB pig jejunal immunity.
- Identify potential biomarkers for pig production health.
Main Methods:
- Immunohistochemistry to assess immunophenotypes.
- Untargeted liquid chromatography-mass spectrometry (LC-MS/MS) for metabolomics.
- Analysis of jejunal chyme from SB and LA piglets.
Main Results:
- SB pigs showed higher anti-inflammatory interleukin-10 (IL-10) and mucosal barrier factors (MUC2, ZO-1).
- SB pigs had lower pro-inflammatory factors (IL-6, IL-1β, TLR-2) and improved gut morphology.
- Taurodeoxycholic acid (TDCA) was significantly higher in SB pigs and positively correlated with barrier function markers.
Conclusions:
- SB pigs possess superior jejunal immune function and mucosal barrier.
- TDCA is identified as a potential regulator of jejunal immunity and barrier function in pigs.
- Findings offer insights into pig breed differences in gut health and potential biomarkers.
