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Color Fundus Imaging Using a High-Magnification Lens for Detecting Subtle Macular Changes in Infants With Congenital
Camila V Ventura1,2,3, Itamara Aragão1, Liana O Ventura1,2
1Department of Ophthalmology, Altino Ventura Foundation, Recife, Brazil.
Insights
High-magnification fundus imaging effectively detects subtle macular changes in infants with congenital Zika syndrome. This advanced imaging aids in diagnosing and understanding the ocular manifestations of this condition.
Area of Science:
- Ophthalmology
- Pediatrics
- Infectious Diseases
Background:
- Congenital Zika syndrome (CZS) is a severe condition affecting infants.
- Ocular abnormalities are a significant concern in CZS.
- Early detection of retinal changes is crucial for management.
Observation:
- This study examined four infants diagnosed with CZS.
- Infants underwent detailed fundus examination and color fundus documentation.
- High-magnification imaging and fluorescein angiography were utilized.
Findings:
- Unilateral retinal findings were observed in all infants.
- Chorioretinal atrophy and pigment mottling were identified in some eyes.
- Subtle macular changes, confirmed by fluorescein angiography, were detected in the contralateral eyes using high-magnification imaging.
Implications:
- High-magnification fundus imaging is a valuable tool for diagnosing subtle macular changes in CZS.
- This technique enhances the documentation of ocular findings in affected infants.
- Improved diagnostic capabilities can lead to better patient outcomes and further research into CZS ocular pathology.
Purpose:
We describe subtle macular changes that were detected by high-magnification color fundus imaging in infants with congenital Zika syndrome.
Methods:
This series included 4 infants (age: 1.4 ± 0.1 years [range, 1.3-1.5 years]) who were serologically confirmed with congenital Zika syndrome, examined under anesthesia, and underwent fundus examination and color fundus documentation. The fundus images were captured using 130° and 80° field lenses. Fluorescein angiography confirmed macular lesions.
Results:
Wide-angle color fundus images detected unilateral retinal findings in all 4 infants. Chorioretinal atrophy was identified in 2 eyes (25%) of 2 infants (50%) and pigment mottling in 3 eyes (37.5%) of 2 infants (50%). High-magnification imaging revealed subtle macular changes in the contralateral eyes of the 4 infants that were confirmed by fluorescein angiography imaging.
Conclusions:
High-magnification fundus imaging can be effective and reliable in revealing and documenting subtle structural changes in the macula of infants with congenital Zika syndrome.
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