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Mechanism of ERK/CREB pathway in pain and analgesia

Weizhe Zhen1,2, Hongjun Zhen3, Yuye Wang2,4

  • 1Graduate School, Beijing University of Chinese Medicine, Beijing, China.

Frontiers in Molecular Neuroscience
|April 3, 2023
PubMed

Insights

The ERK/CREB pathway is crucial in pain and pain relief. This review details its role in pain, analgesia, and potential nervous system side effects from related drugs, offering solutions.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Molecular Biology

Background:

  • Pain pathophysiology research often focuses on Transient Receiver Potential (TRP) channels.
  • The Extracellular Signal-Regulated Kinase/CAMP Response Element Binding Protein (ERK/CREB) pathway's role in pain and analgesia is under-researched.
  • Analgesics targeting the ERK/CREB pathway may present adverse effects requiring medical attention.

Purpose of the Study:

  • To systematically review the ERK/CREB pathway's mechanism in pain and analgesia.
  • To analyze potential adverse neurological effects of ERK/CREB pathway inhibition by analgesics.
  • To propose solutions for managing these adverse effects.

Main Methods:

  • Systematic literature review and synthesis.
  • Analysis of molecular mechanisms.
  • Review of clinical data on analgesic side effects.

Main Results:

  • The ERK/CREB pathway significantly influences pain signaling and resolution.
  • Inhibition of this pathway can lead to various central and peripheral nervous system adverse effects.
  • Specific analgesic mechanisms and their associated neurological risks were identified.

Conclusions:

  • Understanding the ERK/CREB pathway is vital for developing effective and safe analgesics.
  • Targeted therapeutic strategies are needed to mitigate adverse effects.
  • Further research should focus on pathway-specific interventions and neuroprotection.
Keywords:
ERK/CREB pathwayadverse effectsanalgesianervous systempain

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