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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Recent advances in immunotherapy and molecular targeted therapy for gastric cancer

Yuri Yoshinami1, Hirokazu Shoji1

  • 1Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Future Science OA
|April 3, 2023
PubMed

Insights

Advancements in cancer genomics are driving new immunotherapies and targeted drugs for gastric cancer. Future treatments combining immune checkpoint inhibitors with other therapies promise improved patient outcomes.

Area of Science:

  • Oncology
  • Genomics
  • Immunotherapy

Background:

  • Increasing understanding of molecular cancer biology and genomics.
  • Success of immune checkpoint inhibitors (ICIs) in various cancers since 2010.
  • Nivolumab (anti-PD-1 antibody) demonstrated survival benefits in 2017, establishing ICIs in treatment development.

Purpose of the Study:

  • To highlight the development of novel immunotherapies and molecular targeted drugs for gastric cancer.
  • To discuss the impact of immune checkpoint inhibitors (ICIs) on cancer treatment.
  • To explore ongoing clinical trials and future therapeutic prospects.

Main Methods:

  • Review of molecular biological characteristics and cancer genomics in gastric cancer.
  • Analysis of clinical trial data for immunotherapy and combination therapies.
  • Evaluation of the efficacy of immune checkpoint inhibitors, including anti-PD-1 antibodies.

Main Results:

  • Immunotherapy and molecular targeted drugs are being developed for gastric cancer.
  • Immune checkpoint inhibitors (ICIs) have shown significant promise in various cancers.
  • Ongoing trials are investigating combination therapies for enhanced efficacy.

Conclusions:

  • Further improvements in therapeutic outcomes for gastric cancer are anticipated.
  • The combination of immunotherapy with other agents is a key area of ongoing research.
  • Personalized medicine approaches based on molecular characteristics are crucial for gastric cancer treatment.
Keywords:
anti-PD-1 or PD-L1 inhibitorsgastric cancerimmune checkpoint inhibitorsimmunotherapymolecular targeted therapy

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