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Updated: Aug 4, 2025

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CTNNB1 in neurodevelopmental disorders.

Wenting Zhuang1, Tong Ye1, Wei Wang1,2

  • 1Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Wenzhou Medical University, Wenzhou, China.

Frontiers in Psychiatry
|April 3, 2023
PubMed
Summary
This summary is machine-generated.

The CTNNB1 gene, crucial for Wnt signaling, is increasingly linked to neurodevelopmental disorders (NDDs). Understanding CTNNB1

Keywords:
CTNNB1autism spectrum disorderintellectual disabilityneurodevelopmental disordersschizophreniaβ-catenin

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Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • CTNNB1 encodes β-catenin, a key component of the Wnt signaling pathway regulating cellular homeostasis.
  • While extensively studied in cancer, CTNNB1's role in brain function is gaining attention.
  • Neurodevelopmental disorders (NDDs) like intellectual disability, autism, and schizophrenia are increasingly associated with CTNNB1.

Purpose of the Study:

  • To review the physiological and pathological functions of CTNNB1 in the brain.
  • To provide an overview of recent research on CTNNB1 expression and its role in NDDs.
  • To highlight CTNNB1 as a potential high-risk gene and therapeutic target for NDDs.

Main Methods:

  • Literature review of studies on CTNNB1 and its involvement in neurodevelopment.
  • Analysis of research on Wnt signaling pathway dysfunction in NDDs.
  • Synthesis of current findings on CTNNB1 gene expression and function in neurological conditions.

Main Results:

  • Mutations in CTNNB1 disrupt Wnt signaling, affecting gene transcription, synaptic plasticity, neuronal apoptosis, and neurogenesis.
  • Emerging evidence strongly links CTNNB1 to the pathogenesis of various NDDs.
  • CTNNB1 dysregulation impacts critical brain development processes.

Conclusions:

  • CTNNB1 plays a significant role in brain development and function.
  • CTNNB1 is proposed as a high-risk gene for neurodevelopmental disorders.
  • Targeting CTNNB1 may offer a novel therapeutic strategy for NDDs.