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Updated: Aug 4, 2025
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
Management of hepatocellular carcinoma from diagnosis in routine clinical practice
Tasneem Lokhandwala1, Abdalla Aly2, Eileen Farrelly1
1Xcenda LLC, Carrollton, TX 75010, USA.
Aim:
To assess real-world management of patients diagnosed with hepatocellular carcinoma (HCC) within an integrated delivery network.
Materials & Methods:
A retrospective cohort analysis of adults newly diagnosed with HCC from January 2014 to March 2019. Overall survival and treatment journey were assessed over the entire available follow-up period per patient.
Results:
Of the 462 patients, 85% had ≥1 treatment. The 24-month overall survival rate (95% CI) from first treatment was 77% (72-82%). Majority of Child-Pugh class A (71%) and B (60%) patients received locoregional therapy first. Half (53.6%) of the patients with liver transplantation first were Child-Pugh class C patients. Sorafenib was the predominant systemic therapy.
Conclusion:
This integrated delivery network data analysis offers a comprehensive insight into the real-world management of HCC.
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