Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Blood-brain Barrier00:49

The Blood-brain Barrier

47.7K
Overview
47.7K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

906
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
906
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

632
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
632

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-cell RNA profiling of oligodendroglial lineage cells derived from iPSCs carrying Parkinson's disease-relevant LRRK2-G2019S mutation.

iScience·2026
Same author

New insights in multiple sclerosis pathology.

Current opinion in neurology·2026
Same author

Age and Maturation Stage Linked Consequences of Fibrinogen on Human Oligodendroglia.

Journal of neuroscience research·2026
Same author

Enhanced myelination potential of human mature oligodendrocytes by TNF and IFNG combination.

Journal of neuroinflammation·2026
Same author

Convergence and divergence of molecular mechanisms in Hebbian and homeostatic plasticity.

Frontiers in synaptic neuroscience·2026
Same author

Oligodendrocytes under stress in multiple sclerosis.

Neural regeneration research·2026

Related Experiment Video

Updated: Aug 4, 2025

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

12.3K

Seeking neuroprotection in multiple sclerosis: an ongoing challenge.

Jack P Antel1, Timothy E Kennedy1, Tanja Kuhlmann2

  • 1Montreal Neurological Institute, McGill University, Québec, Canada.

The Journal of Clinical Investigation
|April 3, 2023
PubMed
Summary

This study explores targeting neuron-oligodendrocyte potassium transport in the central nervous system (CNS) as a neuroprotective strategy for multiple sclerosis (MS). Findings in experimental MS models and patient tissues suggest a potential therapeutic pathway.

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.5K
An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices
06:36

An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices

Published on: February 5, 2015

7.1K

Related Experiment Videos

Last Updated: Aug 4, 2025

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

12.3K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.5K
An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices
06:36

An Ex vivo Model of an Oligodendrocyte-directed T-Cell Attack in Acute Brain Slices

Published on: February 5, 2015

7.1K

Area of Science:

  • Neuroscience
  • Immunology
  • Neurology

Background:

  • Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disorder characterized by inflammation and demyelination.
  • Variable recovery in MS highlights the need for neuroprotective strategies.

Purpose of the Study:

  • To investigate targeting neuron-oligodendrocyte potassium shuttling at the nodes of Ranvier as a neuroprotective strategy in experimental MS.
  • To evaluate the impact of pharmacologic intervention on these pathways.

Main Methods:

  • Examination of MS features in established disease models.
  • Investigation of pharmacologic interventions.
  • Evaluation of pathway status in tissues from MS patients.

Main Results:

  • The study provides a template for defining the physiologic properties of a potential protective pathway.
  • Evidence suggests the feasibility of targeting potassium shuttling in experimental MS.

Conclusions:

  • Targeting neuron-oligodendrocyte potassium shuttling presents a potential neuroprotective strategy for inflammatory demyelination in MS.
  • Further research is needed to translate these findings into clinical therapy for MS patients.