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Intraocular neuroectodermal embryonal tumor in two rabbits.

Carmon Co1, Kelsey Brakel2, Chantale L Pinard3

  • 1Department of Pathobiology, Ontario Veterinary College, University of Guelph, Ontario, Canada.

Veterinary Ophthalmology
|April 3, 2023
PubMed
Summary
This summary is machine-generated.

Spontaneous intraocular neuroectodermal embryonal tumors are rare in young rabbits. Early enucleation is recommended for refractory eye disease to manage these neoplasms.

Keywords:
PNETintraocular neoplasmmedulloepitheliomaneuroectodermal embryonal tumorretinoblastoma

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Area of Science:

  • Veterinary Pathology
  • Ophthalmology
  • Oncology

Background:

  • Spontaneous intraocular tumors are infrequently documented in rabbits, a common laboratory animal.
  • Neuroectodermal embryonal tumors, previously termed primitive neuroectodermal tumors, are exceptionally rare ocular neoplasms.

Observation:

  • Two cases of intraocular neuroectodermal embryonal tumors were identified in young rabbits.
  • Histopathological examination revealed characteristic rosettes and pseudorosettes, mirroring human tumor morphology.
  • Immunohistochemistry confirmed the neuroectodermal subtype using neuronal markers: SRY-box transcription factor 2, microtubule-associated protein 2, neuronal nuclear protein, and neuron-specific enolase.

Findings:

  • Tumor cells displayed immunoreactivity for key neuronal markers, supporting a neuroectodermal origin.
  • Metastasis to the contralateral conjunctiva was observed in one rabbit.
  • These findings highlight the potential for intraocular neoplasms in young rabbits.

Implications:

  • Intraocular neoplasms should be considered in young rabbits presenting with ocular abnormalities.
  • Enucleation of affected eyes is crucial for clinical management of refractory intraocular disease.
  • This study contributes to the understanding of rare tumors in laboratory animals, informing veterinary oncology and ophthalmology.