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Updated: Aug 4, 2025

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

17.0K

Hypertension and cellular senescence

Baris Afsar1, Rengin Elsurer Afsar2

  • 1Department of Nephrology, School of Medicine, Suleyman Demirel University, Isparta, Turkey. afsarbrs@yahoo.com.

Biogerontology
|April 3, 2023
PubMed

Insights

Essential hypertension is linked to biological aging. This review explores shared pathways like inflammation and oxidative stress, and how hypertension treatments may affect cellular aging.

Area of Science:

  • Gerontology
  • Cardiovascular Medicine
  • Cellular Biology

Background:

  • Essential hypertension is a global health issue.
  • Elevated blood pressure (BP) correlates with both chronological and biological aging.
  • Common mechanisms link cellular aging and BP regulation, including inflammation, oxidative stress, and mitochondrial dysfunction.

Purpose of the Study:

  • To summarize shared mechanisms between cellular senescence and hypertension (HT).
  • To review the impact of antihypertensive drugs on cellular senescence.
  • To identify areas for future research.

Main Methods:

  • Literature review of studies on cellular senescence and hypertension.
  • Analysis of common pathways involved in aging and BP regulation.
  • Examination of existing data on antihypertensive and senolytic drug effects.

Main Results:

  • Identified shared pathways including inflammation, oxidative stress, mitochondrial dysfunction, air pollution, decreased klotho activity, renin-angiotensin system activation, and gut dysbiosis.
  • Noted that some antihypertensive drugs possess anti-senescent properties.
  • Observed that senolytic drugs can lower BP.

Conclusions:

  • Cellular senescence and hypertension share common underlying mechanisms.
  • Antihypertensive medications may offer benefits beyond BP reduction by targeting senescence.
  • Further research is warranted to explore senolytic therapies for hypertension.

Keywords:
Blood pressureCellular senescenceHypertensionSenescence‐associated secretory phenotypeSenolytics

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