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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

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Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
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Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

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Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Hypertension I: Introduction01:28

Hypertension I: Introduction

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Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
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Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

36
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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Induction and Validation of Cellular Senescence in Primary Human Cells
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Hypertension and cellular senescence.

Baris Afsar1, Rengin Elsurer Afsar2

  • 1Department of Nephrology, School of Medicine, Suleyman Demirel University, Isparta, Turkey. afsarbrs@yahoo.com.

Biogerontology
|April 3, 2023
PubMed
Summary
This summary is machine-generated.

Essential hypertension is linked to biological aging. This review explores shared pathways like inflammation and oxidative stress, and how hypertension treatments may affect cellular aging.

Keywords:
Blood pressureCellular senescenceHypertensionSenescence‐associated secretory phenotypeSenolytics

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Area of Science:

  • Gerontology
  • Cardiovascular Medicine
  • Cellular Biology

Background:

  • Essential hypertension is a global health issue.
  • Elevated blood pressure (BP) correlates with both chronological and biological aging.
  • Common mechanisms link cellular aging and BP regulation, including inflammation, oxidative stress, and mitochondrial dysfunction.

Purpose of the Study:

  • To summarize shared mechanisms between cellular senescence and hypertension (HT).
  • To review the impact of antihypertensive drugs on cellular senescence.
  • To identify areas for future research.

Main Methods:

  • Literature review of studies on cellular senescence and hypertension.
  • Analysis of common pathways involved in aging and BP regulation.
  • Examination of existing data on antihypertensive and senolytic drug effects.

Main Results:

  • Identified shared pathways including inflammation, oxidative stress, mitochondrial dysfunction, air pollution, decreased klotho activity, renin-angiotensin system activation, and gut dysbiosis.
  • Noted that some antihypertensive drugs possess anti-senescent properties.
  • Observed that senolytic drugs can lower BP.

Conclusions:

  • Cellular senescence and hypertension share common underlying mechanisms.
  • Antihypertensive medications may offer benefits beyond BP reduction by targeting senescence.
  • Further research is warranted to explore senolytic therapies for hypertension.