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Related Concept Videos

Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

548
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
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Anatomy of the Intestines01:23

Anatomy of the Intestines

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Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
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Related Experiment Video

Updated: Aug 4, 2025

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

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Gut Microbiome in Sepsis.

Nathan J Klingensmith1, Craig M Coopersmith2

  • 1Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Surgical Infections
|April 3, 2023
PubMed
Summary
This summary is machine-generated.

Sepsis disrupts the gut microbiome, leading to increased intestinal permeability and worse outcomes. Restoring microbial diversity may improve survival in sepsis patients.

Area of Science:

Keywords:
gutintestinemicrobiomepathobiomeprobioticssepsis

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  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • The gut microbiome's role in sepsis-induced multiple organ dysfunction is increasingly recognized.
  • Sepsis significantly alters the gut microbiome, shifting it from a healthy state to a pathobiome.

Conclusions:

  • Targeting the gut microbiome may offer a therapeutic avenue for sepsis.
  • Further research is needed to validate therapies like probiotics, prebiotics, and fecal microbial transplantation for sepsis management.