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Related Experiment Video

Updated: Aug 4, 2025

Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis

Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis

Published on: February 13, 2014

BDNF signaling in correlation-dependent structural plasticity in the developing visual system.

Elena Kutsarova^1,2, Anne Schohl¹, Martin Munz^1,3,4

¹Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.

|April 3, 2023

Summary

This summary is machine-generated.

Neural activity patterns guide axon development. Brain-derived neurotrophic factor (BDNF) signaling is crucial for both synapse stabilization (Hebbian plasticity) and growth in response to uncorrelated inputs (Stentian plasticity).

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Area of Science:

Neuroscience
Developmental Biology
Cell Biology

Background:

Topographic map refinement during development is instructed by patterned neural activity.
Axon development involves Hebbian structural plasticity (activity-dependent synapse stabilization) and Stentian structural plasticity (activity-independent growth).

Purpose of the Study:

To investigate the role of brain-derived neurotrophic factor (BDNF) signaling in Hebbian and Stentian structural plasticity.
To elucidate the specific roles of presynaptic and postsynaptic BDNF signaling pathways in axon refinement.

Main Methods:

Utilized visual stimulation to control neural activity correlation in retinal ganglion cell (RGC) axons in Xenopus laevis tadpoles.
Employed multiphoton live imaging to observe ipsilateral (ipsi) axon development.
Disrupted brain-derived neurotrophic factor (BDNF) signaling pathways, including p75NTR and TrkB receptors.

Main Results:

Presynaptic p75NTR and TrkB are essential for Stentian axonal branch addition.
Postsynaptic BDNF signaling is necessary for Hebbian axon stabilization.
BDNF signaling suppresses local branch elimination in response to correlated neural activity.
p75NTR knockdown reduced contralateral RGC axon branch elongation and arbor field volume.

Conclusions:

BDNF signaling differentially regulates Hebbian and Stentian structural plasticity in developing axons.
Both presynaptic and postsynaptic BDNF pathways are critical for activity-dependent axon refinement.
Targeted manipulation of BDNF signaling offers insights into neural circuit formation.