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Determination of Inorganic Arsenic in a Wide Range of Food Matrices using Hydride Generation - Atomic Absorption Spectrometry.
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Elemental impurities determination in bromhexine hydrochloride injections

Shujuan Xu1, Lei Zhang1, Qingshan Bai1

  • 1Linyi Inspection and Testing Center, Linyi 276000, China.

Journal of Pharmaceutical and Biomedical Analysis
|April 3, 2023
PubMed
Summary

A new ICP-MS method accurately measured 31 elemental impurities in bromhexine hydrochloride injections. While all impurities were below safety limits, significant variations between manufacturers highlight potential contamination risks.

Keywords:
Bromhexine hydrochloride injectionsElemental impuritiesInductively coupled plasma mass spectrometryInternational Council for HarmonisationQuantitative determination

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