Hepatology Genome Rounds: An interdisciplinary approach to integrate genomic data into clinical practice

Area of Science:

• Genomics
• Hepatology
• Clinical Medicine

Background:

• Whole-exome sequencing (WES) has advanced the genetic diagnosis of liver diseases.
• Genetic insights improve patient management, treatment, and prognostication.
• Limited genetic training hinders hepatologist adoption of genetic testing.

Purpose of the Study:

• To demonstrate the value of Hepatology Genome Rounds in integrating genomic and phenotypic data.
• To facilitate accurate diagnosis and management of liver diseases.
• To disseminate genomic knowledge and provide education in genomic medicine.

Main Methods:

• Established an interdisciplinary forum (Hepatology Genome Rounds).
• Highlighted clinical cases with genetic and phenotypic information.
• Described a single-center experience and practical considerations.

Main Results:

• Hepatology Genome Rounds effectively integrate genotypic and phenotypic information.
• The forum enables accurate diagnosis and appropriate patient management.
• It serves as a platform for genomic knowledge dissemination and provider education.

Conclusions:

• Hepatology Genome Rounds are crucial for advancing genomic medicine in hepatology.
• This educational format can be adopted by other institutions and specialties.
• Widespread adoption will further integrate genomic information into clinical practice.