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DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart,...
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Updated: Aug 4, 2025

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
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Published on: June 16, 2011

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How often are replication attempts questioned?

Przemysław G Hensel1

  • 1Faculty of Management, University of Warsaw, Warsaw, Poland.

Accountability in Research
|April 3, 2023
PubMed
Summary
This summary is machine-generated.

Fear of retaliation for failed replications is minimal in psychology. Open data reduces negative attention, and replies to replications receive less engagement, shielding original research.

Keywords:
Replicationsresearch cultureself-correction in science

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Area of Science:

  • Psychology
  • Scientific Publishing
  • Research Integrity

Background:

  • Replication crisis in psychology.
  • Fear of author retaliation as a barrier to replication.
  • Paucity of replications in scientific literature.

Purpose of the Study:

  • Measure the frequency and attention of negative responses to replications in psychology.
  • Investigate the impact of open data on negative responses.
  • Assess the attention received by replies to replications.

Main Methods:

  • Three studies analyzing negative mentions, post-publication peer review comments, and stand-alone replies.
  • Comparison of replications with non-replication papers.
  • Analysis of citations and readership for replies to replications.

Main Results:

  • Independent failed replications attract slightly more negative mentions, but open data reduces this.
  • No difference in comments on post-publication peer-review sites.
  • Stand-alone replies to replications are less cited and read than the replications themselves.

Conclusions:

  • Fear of retaliation is not a significant barrier to replication.
  • Open data mitigates negative responses to replications.
  • The scientific community largely shields published research from critical questioning.