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Related Experiment Videos

Ascorbate interference in the estimation of urinary glucose by test strips.

B Berg

    Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Fur Klinische Chemie Und Klinische Biochemie
    |January 1, 1986
    PubMed
    Summary

    Ascorbate interference in urine glucose test strips can cause false negatives, particularly in diabetes screening. A new Boehringer Mannheim test strip shows significantly reduced interference, improving diagnostic accuracy.

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    Area of Science:

    • Clinical Chemistry
    • Diagnostic Testing
    • Urine Analysis

    Background:

    • Current urine glucose test strips are susceptible to interference from ascorbate (vitamin C).
    • This interference can lead to inaccurate false-negative results, potentially impacting the screening for conditions like diabetes.

    Purpose of the Study:

    • To evaluate the in vitro interference of ascorbate on six different urine glucose test strips.
    • To identify and quantify the extent of ascorbate interference across various test strip brands.
    • To assess a new test strip for its performance in the presence of ascorbate.

    Main Methods:

    • In vitro evaluation of six commercially available urine glucose test strips.
    • Testing for interference by varying concentrations of ascorbate in urine samples with known glucose levels.
    • Calculation of interference coefficients to quantify ascorbate's effect on each test strip.

    Main Results:

    • Significant variation in ascorbate interference was observed among the tested urine glucose strips.
    • Interference was most pronounced at lower glucose concentrations.
    • A new Boehringer Mannheim test strip (BM 33.071) demonstrated markedly reduced ascorbate interference, maintaining accurate readings even at high ascorbate levels.

    Conclusions:

    • Ascorbate interference is a significant issue affecting the reliability of standard urine glucose test strips.
    • The new Boehringer Mannheim test strip offers improved accuracy due to its minimal susceptibility to ascorbate interference.
    • This advancement has implications for more reliable diabetes screening and monitoring using urine glucose tests.

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