Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Viruses with RNA Genomes

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...

What are Viruses?

What are Viruses?

Introduction to Virus

Introduction to Virus

Viruses are unique biological entities that blur the boundary between living and non-living systems. Although they lack cellular structure and metabolic processes, they can exhibit characteristics of life when infecting a host. Their defining feature is a nucleic acid core, composed of either DNA or RNA, encapsulated within a protein coat called a capsid. This simple structure allows them to invade host cells and use their machinery for replication efficiently.Viral Structure and...

Size and Structure of Viral Genomes

Size and Structure of Viral Genomes

Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...

Viruses of Archaea

Viruses of Archaea

Archaeal viruses play a crucial role in the ecosystems of extremophilic archaea, particularly those belonging to the phyla Euryarchaeota and Crenarchaeota. By shaping host evolution and facilitating gene transfer, these viruses influence microbial communities and contribute to genetic diversity in extreme environments. The archaea they infect thrive in acidic hot springs and hydrothermal vents characterized by high temperatures and low pH. Archaeal viruses exhibit remarkable structural...

Viral Recombination

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Strengthened Ebola surveillance in France during a major outbreak in West Africa: March 2014-January 2016.

Epidemiology and infection·2017

Same author

Present-day uplift of the western Alps.

Scientific reports·2016

Same author

Ebola and Marburg haemorrhagic fever viruses: major scientific advances, but a relatively minor public health threat for Africa.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2011

Same author

[Ebola and Marburg hemorrhagic fever viruses: update on filoviruses].

Medecine tropicale : revue du Corps de sante colonial·2011

Same author

The 2010 Mw 8.8 Maule megathrust earthquake of Central Chile, monitored by GPS.

Science (New York, N.Y.)·2011

Same author

Poly(I)-poly(C12U) but not ribavirin prevents death in a hamster model of Nipah virus infection.

Antimicrobial agents and chemotherapy·2006

Same journal

[From rhizomania to viral RNAs structure functions].

Virologie (Montrouge, France)·2026

Same journal

[Characteristics of viral gastroenteritis in solid organ transplant patients].

Virologie (Montrouge, France)·2026

Same journal

[ResaFlu/FluResearchNet International symposium,Toulouse, November 26-27, 2025].

Virologie (Montrouge, France)·2026

Same journal

[ViRAE 2025: a landmark inaugural edition for virology at INRAE].

Virologie (Montrouge, France)·2026

Same journal

[13<sup>rd</sup> Cytokines annual meeting, Novembre 2-5 2025, Seattle, USA].

Virologie (Montrouge, France)·2026

Same journal

[Annual report of the French Society for Virology].

Virologie (Montrouge, France)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Aug 4, 2025

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

Published on: March 2, 2016

[Filovirus].

M-C Georges-Courbot¹, S Baize², A-J Georges³

¹Unité de biologie des infections virales émergentes, Institut Pasteur, 21 avenue Tony-Garnier, 69365 Lyon, Inserm, Laboratoire P4 Jean Mérieux, Lyon.

Virologie (Montrouge, France)

|April 4, 2023

Summary

This summary is machine-generated.

Marburg and Ebola viruses cause deadly hemorrhagic fever outbreaks. Research shows promising treatments and vaccines in primate models, offering hope against these mysterious viral threats.

Keywords:

filovirus inter human transmission mortality prevention virus Ebola virus Marburg

More Related Videos

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses

Published on: December 29, 2015

Mosquito-Associated Virus Isolation from Field-Collected Mosquitoes

Mosquito-Associated Virus Isolation from Field-Collected Mosquitoes

Published on: August 31, 2022

Related Experiment Videos

Last Updated: Aug 4, 2025

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

Published on: March 2, 2016

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses

Published on: December 29, 2015

Mosquito-Associated Virus Isolation from Field-Collected Mosquitoes

Mosquito-Associated Virus Isolation from Field-Collected Mosquitoes

Published on: August 31, 2022

Area of Science:

Virology
Immunology
Infectious Diseases

Context:

Marburg and Ebola viruses frequently emerge in Africa, causing high-mortality viral hemorrhagic fever outbreaks.
Despite decades of research, the viral reservoir and pathogenicity mechanisms remain poorly understood.
A defective or inadapted immune response is implicated as a key factor in disease severity.

Purpose:

To review current understanding and research progress on Marburg and Ebola viruses.
To highlight advancements in potential treatments and vaccine development for filovirus infections.

Summary:

Encouraging results have been observed in non-human primate models for filovirus infection treatments, including recombinant nematode anticoagulant protein, antisense phosphorodiamidate morpholino oligomers, and small interfering RNA.
Vaccine candidates, such as recombinant vesicular stomatitis virus (VSV) expressing filovirus glycoproteins (GP) and adenovirus expressing filovirus GP and nucleoprotein (NP), show promise in macaque models.

Impact:

These findings offer potential therapeutic and prophylactic strategies against Marburg and Ebola viruses.
Further development could lead to the first available treatments and vaccines for humans, mitigating future outbreaks.