Predictive value of peripheral lymphocyte subsets for the disease progression in patients with sepsis

To investigate the predictive value of peripheral lymphocyte subsets for sepsis progression.

Patients with sepsis were divided into the improved group (n = 46) and severe group (n = 39) according to disease progression. Flow cytometric analysis was performed to enumerate absolute counts of peripheral lymphocyte subsets. Logistic regression analyses were conducted to identify clinical factors linked to sepsis progression.

The absolute counts of peripheral lymphocyte subsets were markedly decreased in septic patients compared with healthy controls. After treatment, the absolute counts of lymphocytes, CD3⁺ T cells, and CD8⁺ T cells were restored in the improved group, and reduced in the severe group. Logistic regression analysis indicated that a low CD8⁺ T cells count was a risk factor for sepsis progression. Receiver operating characteristic curve analysis revealed that CD8⁺ T cells count had the greatest ability to predict sepsis progression.

The absolute counts of CD3⁺ T cells, CD4⁺ T cells, CD8⁺ T cells, B cells, and natural killer cells were significantly higher in the improved group than the severe group. CD8⁺ T cells count was predictive of sepsis progression. Lymphopenia and CD8⁺ T cells depletion were associated with the clinical outcomes of sepsis, suggesting that CD8⁺ T cells have potential as a predictive biomarker and therapeutic target for patients with sepsis.