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Coccidioidomycosis in Joint Replacement: A Review of the Literature With Case Presentations
Francesca Anna Giordani1, Brendan Kiernan1, Mauro Giordani1
1Department of Orthopaedic Surgery, University of California Davis Health, Sacramento, CA, USA.
Abstract:
Coccidioidomycosis is a fungal infection endemic to certain regions of the Americas. In some cases, the organism may infect the musculoskeletal system, resulting in a prosthetic joint infection (PJI). Due to its difficulty in diagnosis, treatment of coccidioidomycosis in PJI is often delayed. Furthermore, with limited number of case reports, a standard of care in treatment has yet to be established. We present 2 cases of coccidioidomycosis PJI, the extensive evaluation that led to the diagnosis, and the treatment provided. This report highlights the natural progression of coccidioidomycosis in a prosthetic joint, the diagnostic features including histology, advanced imaging, and final treatment administered.
Insights
Coccidioidomycosis fungal infections can affect prosthetic joints (PJI). Delayed diagnosis and limited case reports complicate treatment, necessitating further research for established care standards.
Area of Science:
- Mycology
- Infectious Diseases
- Orthopedic Surgery
Background:
- Coccidioidomycosis is a fungal infection endemic to the Americas.
- It can affect the musculoskeletal system, leading to prosthetic joint infections (PJI).
- Diagnosis and treatment of coccidioidomycosis in PJI are challenging due to rarity and diagnostic difficulty.
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