Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

1.3K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.3K
Spontaneous and Induced Mutations01:30

Spontaneous and Induced Mutations

66
Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
66
Cancer Prevention02:59

Cancer Prevention

6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.2K
Gene-Environment Interactions01:20

Gene-Environment Interactions

387
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
387
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

3.6K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
3.6K
Epigenetic Regulation01:37

Epigenetic Regulation

3.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regulatory approach to manipulated organs in Europe: preserving human organs as non-commercial goods.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same author

Protecting organ donation and transplantation programmes from regulatory uncertainty: an urgent appeal to the European Parliament, Council and Commission.

The Lancet regional health. Europe·2026
Same author

Decellularized Dermis ECM-Based Melanoma-on-a-Chip Model with Integrated Lymphatic and Vascular Networks for High-Throughput Drug Testing.

ACS applied bio materials·2026
Same author

Dynamic prediction of death risk given a renewal hospitalization process.

Statistical methods in medical research·2025
Same author

Validation of an in vitro muscle platform to evaluate myogenesis and calcium handling in control and dystrophic human myotubes.

Scientific reports·2025
Same author

Understanding the COVID-19 pandemic through bayesian spatio-temporal modeling of several outcomes.

Spatial and spatio-temporal epidemiology·2025

Related Experiment Video

Updated: Aug 4, 2025

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
12:15

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter

Published on: May 29, 2019

8.8K

Age or lifestyle-induced accumulation of genotoxicity is associated with a length-dependent decrease in gene

Olga Ibañez-Solé1, Irantzu Barrio2,3, Ander Izeta1,4

  • 1Tissue Engineering Group; Biodonostia Health Research Institute, 20014 Donostia-San Sebastián, Spain.

Iscience
|April 4, 2023
PubMed
Summary

DNA damage accumulates in longer genes, leading to their underexpression with aging. This newly identified hallmark of aging impacts gene expression across species and in disease.

Keywords:
Biological sciencesMolecular GeneticsMolecular biologyOmicsTranscriptomics

More Related Videos

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
08:46

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

15.7K
The Lambda Select cII Mutation Detection System
07:08

The Lambda Select cII Mutation Detection System

Published on: April 26, 2018

8.0K

Related Experiment Videos

Last Updated: Aug 4, 2025

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
12:15

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter

Published on: May 29, 2019

8.8K
Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
08:46

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

15.7K
The Lambda Select cII Mutation Detection System
07:08

The Lambda Select cII Mutation Detection System

Published on: April 26, 2018

8.0K

Area of Science:

  • Genomics
  • Molecular Biology
  • Aging Research

Background:

  • DNA damage is a known aging driver.
  • Damage accumulation is influenced by gene length.
  • This length-dependent damage may affect gene expression.

Purpose of the Study:

  • To investigate the relationship between gene length, DNA damage, and gene expression during aging.
  • To identify if length-dependent gene underexpression is a hallmark of aging.

Main Methods:

  • Analysis of gene expression data from single-cell RNA sequencing in aging mouse and human samples.
  • Examination of gene expression patterns in relation to gene length across different tissues and cell types.
  • Correlation analysis of length-dependent gene expression changes with environmental exposures and genetic disorders.

Main Results:

  • A consistent age-associated, length-dependent underexpression of genes was observed across species, tissues, and cell types.
  • This phenomenon was also linked to UV radiation, smoke exposure, and progeroid syndromes (Cockayne syndrome, trichothiodystrophy).
  • Genes globally underexpressed with aging were significantly longer than overexpressed genes.

Conclusions:

  • Length-dependent gene underexpression is a previously unrecognized hallmark of aging.
  • Accumulation of genotoxicity in longer genes may impair RNA polymerase II processivity, contributing to aging.
  • This finding provides new insights into the molecular mechanisms of aging.