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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
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Genotypic Diversity of Childhood Rhinovirus Infections

Kathryn M Schmit1, Gregory P DeMuri1, Jens C Eickhoff1

  • 1Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

Journal of the Pediatric Infectious Diseases Society
|April 4, 2023
PubMed

Insights

Rhinovirus (RV) species and types were analyzed in children, both with and without symptoms, over several years. Rhinovirus-A and Rhinovirus-C were the most common types found in all study participants.

Area of Science:

  • Pediatric infectious diseases
  • Virology
  • Respiratory virus epidemiology

Background:

  • Rhinovirus (RV) is a common respiratory pathogen in children.
  • Understanding RV distribution is crucial for managing respiratory illnesses.
  • Previous studies have not fully characterized RV species and types in both symptomatic and asymptomatic pediatric populations.

Purpose of the Study:

  • To describe the distribution of rhinovirus (RV) by species and type.
  • To compare RV distribution in symptomatic versus asymptomatic children.
  • To conduct a multi-year prospective analysis of pediatric RV infections.

Main Methods:

  • Prospective cohort study design.
  • Multi-year data collection from pediatric participants.
  • Identification and typing of rhinovirus (RV) species and types.

Main Results:

  • A broad and diverse range of RV types were identified.
  • RV species A (RV-A) and C (RV-C) were predominant across all study visits.
  • Similar RV type distribution was observed in both symptomatic and asymptomatic children.

Conclusions:

  • Rhinovirus (RV) infections are common and diverse in children, irrespective of symptoms.
  • RV-A and RV-C are the dominant rhinovirus species in the pediatric population.
  • Further research into the clinical impact of specific RV types is warranted.

Keywords:
childrenepidemiologyrespiratory infectionrhinovirus

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