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The human microbiota key role in the bone metabolism activity
A M Inchingolo1, C Gargiulo Isacco, A D Inchingolo
1Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy. francesco.inchingolo@uniba.it.
European Review for Medical and Pharmacological Sciences
|April 4, 2023
Summary
The gut microbiota influences bone health through complex interactions. Understanding gut hormones
Area of Science:
- Microbiome research
- Bone biology
- Endocrinology
Background:
- The gut microbiota (GM) plays a role in bone homeostasis, but mechanisms are unclear.
- Host-microbiota crosstalk significantly impacts bone metabolism and fracture risk.
- Aging-related skeletal frailty necessitates understanding the gut-bone axis.
Approach:
- This review synthesizes current knowledge on gut-derived hormones regulating bone homeostasis.
- It emphasizes the gut-bone axis and its role in bone regeneration.
- The review explores microbiota-related pathways influencing bone metabolism.
Key Points:
- Gut hormones are crucial regulators of bone homeostasis.
- The gut microbiota influences bone metabolism and may affect fracture risk.
- Understanding these interactions is key for preventing osteoporosis and skeletal frailty.
Conclusions:
- Further research into microbiota-bone metabolism pathways can reveal novel therapeutic targets.
- Elucidating gut hormone actions on bone offers new strategies for skeletal health.
- Targeting the gut-bone axis may prevent and treat age-related bone loss.
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