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Related Experiment Videos

Stapedius reflex in multiple sclerosis.

H Mattle, T Spillmann, N Dillier

    Journal of Neurology
    |April 1, 1986
    PubMed
    Summary
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    The stapedius reflex (StR) test can detect early signs of multiple sclerosis (MS). Abnormal StR results in MS patients suggest brainstem lesions, aiding in early MS diagnosis.

    Area of Science:

    • Neurology
    • Audiology
    • Medical Diagnostics

    Background:

    • Multiple sclerosis (MS) is a chronic neurological disease.
    • Early detection of MS is crucial for effective management.
    • Subclinical brainstem lesions can occur in MS patients.

    Purpose of the Study:

    • To investigate the utility of the stapedius reflex (StR) test in identifying brainstem lesions in multiple sclerosis (MS) patients.
    • To assess differences in StR parameters between MS patients and healthy controls.
    • To evaluate the StR as a potential tool for early MS diagnosis.

    Main Methods:

    • Impedance audiometry was used to measure ipsilateral and contralateral stapedius reflexes.
    • The study included 48 patients diagnosed with multiple sclerosis and 26 healthy controls.

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  • Analysis focused on reflex amplitudes, onset latencies, and contralateral reflex thresholds.

    • Main Results:

    • Multiple sclerosis patients exhibited significantly smaller reflex amplitudes and longer onset latencies compared to controls.
    • Higher contralateral reflex thresholds were observed in MS patients.
    • Abnormalities in ipsi- and/or contralateral StRs, based on onset latencies, were detected in 33% of all MS patients and 39% of definite MS cases.

    Conclusions:

    • The stapedius reflex test is a valuable tool for detecting subclinical brainstem lesions in MS.
    • Abnormalities in StR parameters can contribute to the early diagnosis of multiple sclerosis.
    • StR testing offers a non-invasive method to support MS diagnosis and monitoring.