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Circulating HDAC4 reflects lipid profile, coronary stenosis and inflammation in coronary heart disease patients

Zhangli Guo1, Yanqiang Wu1, Qiang Feng1

  • 1Department of Cardiology, HanDan Central Hospital, Handan, 056002, China.

Biomarkers in Medicine
|April 4, 2023
PubMed

Insights

Histone deacetylase 4 (HDAC4) is decreased in coronary heart disease (CHD) patients, indicating its value in disease monitoring. However, HDAC4 levels do not predict major adverse cardiovascular event risk in these patients.

Area of Science:

  • Biochemistry
  • Cardiology
  • Molecular Biology

Background:

  • Coronary heart disease (CHD) poses a significant global health burden.
  • Identifying reliable biomarkers for CHD diagnosis and prognosis is crucial.
  • Histone deacetylase 4 (HDAC4) role in cardiovascular disease requires further elucidation.

Purpose of the Study:

  • To investigate the clinical significance of serum HDAC4 levels in patients with coronary heart disease (CHD).
  • To assess the association of HDAC4 with clinical parameters and inflammatory markers in CHD.
  • To evaluate the prognostic value of HDAC4 in predicting major adverse cardiovascular events (MACE) in CHD patients.

Main Methods:

  • Serum samples were collected from 180 CHD patients and 50 healthy controls.
  • Enzyme-linked immunosorbent assay (ELISA) was used to quantify serum HDAC4 levels.
  • Statistical analyses were performed to correlate HDAC4 levels with clinical data, inflammatory markers, and MACE.

Main Results:

  • Serum HDAC4 levels were significantly lower in CHD patients compared to healthy controls (p < 0.001).
  • HDAC4 showed negative correlations with serum creatinine, low-density lipoprotein cholesterol, and C-reactive protein in CHD patients.
  • HDAC4 was inversely associated with pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-17A), VCAM1, and the Gensini score.

Conclusions:

  • Circulating HDAC4 levels may serve as a valuable biomarker for monitoring disease status in CHD.
  • HDAC4 levels were not found to be predictive of major adverse cardiovascular event risk in this cohort.
  • Further research is warranted to fully understand the role of HDAC4 in the pathogenesis and progression of CHD.

Keywords:
MACE riskadhesion moleculescoronary heart diseasehistone deacetylase 4inflammatory cytokineslipid profile

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