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Updated: Aug 4, 2025

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms
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Epitranscriptomics: new players in an old game.

Alba Coego1, Helena Covelo-Molares1, Diana Guallar1

  • 1Epitranscriptomics and Ageing Group. Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela (USC), Santiago de Compostela 15782, Spain.

Biochemical Society Transactions
|April 4, 2023
PubMed
Summary
This summary is machine-generated.

The epitranscriptome, or chemical RNA modifications, influences ageing and lifespan. Dysregulation of RNA modifications is linked to age-related diseases, suggesting new therapeutic targets.

Keywords:
5-methylcytosineN6-methyladenosineRNA modificationsage-related diseasesageing hallmarksepitranscriptome

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Area of Science:

  • Molecular Biology
  • Genetics
  • Gerontology

Background:

  • Ageing is a complex biological process with poorly understood molecular drivers, despite being a major risk factor for numerous diseases.
  • Over 170 chemical RNA modifications, collectively termed the epitranscriptome, regulate RNA metabolism and are increasingly implicated in ageing.
  • Dysregulation of the epitranscriptome is linked to age-related diseases and ageing hallmarks in mammals.

Approach:

  • This review synthesizes current research on RNA modifications, their regulatory enzymes, and their connection to ageing.
  • It explores the potential role of RNA modifications in regulating non-coding RNAs involved in ageing, such as transposable elements and tRNA fragments.
  • The review includes a reanalysis of mouse tissue datasets to identify age-related transcriptional changes in RNA modification machinery.

Key Points:

  • Mutations in RNA modifying enzymes affect lifespan in model organisms.
  • Changes in mRNA modifications and RNA modifier expression are observed with age and in neurodegenerative diseases.
  • The epitranscriptome is emerging as a key regulator of ageing and lifespan.

Conclusions:

  • RNA modifications and their regulatory enzymes are critical players in the ageing process.
  • Understanding the epitranscriptome offers novel therapeutic avenues for age-related diseases.
  • Further research into RNA modifications' role in ncRNAs like transposable elements and tRNA fragments is warranted.