Jove
Visualize
Contact Us

Related Experiment Videos

Reduced beta-adrenoceptor sensitivity in the elderly.

R E Vestal, A J Wood, D G Shand

    Clinical Pharmacology and Therapeutics
    |August 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Life on the dry side: a roadmap to understanding desiccation tolerance and accelerating translational applications.

    Nature communications·2025
    Same author

    The utility of whole-genome sequencing to identify likely transmission pairs for pathogens with slow and variable evolution.

    Epidemics·2024
    Same author

    The readability and reliability of online information about adenoidectomy.

    The Journal of laryngology and otology·2021
    Same author

    FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy.

    Nature communications·2021
    Same author

    A policy of day-case sinonasal surgery is safe, well tolerated and cost-effective.

    The Journal of laryngology and otology·2021
    Same author

    Cellular rescue in a zebrafish model of congenital muscular dystrophy type 1A.

    NPJ Regenerative medicine·2019
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Aging reduces the body's sensitivity to beta-adrenergic drugs like isoproterenol and propranolol. This diminished responsiveness affects both how these medications work and their overall effectiveness in older adults.

    Area of Science:

    • Pharmacology
    • Gerontology
    • Cardiovascular Physiology

    Background:

    • Beta-adrenoceptors play a crucial role in regulating heart rate and other cardiovascular functions.
    • Age-related changes in receptor sensitivity can impact drug efficacy and patient outcomes.

    Purpose of the Study:

    • To investigate the effect of aging on the sensitivity to beta-adrenergic agonist (isoproterenol) and antagonist (propranolol) drugs.
    • To determine how age influences the dose-response relationship for these medications.

    Main Methods:

    • 27 male volunteers aged 21-73 years participated in the study.
    • Isoproterenol dose-response assessed by heart rate increase (I25).
    • Propranolol's effect on I25 and free plasma concentration measured.

    Related Experiment Videos

    Main Results:

    • The dose of isoproterenol required to increase heart rate by 25 bpm (I25) increased with age.
    • The effectiveness of a given propranolol concentration diminished progressively with age.
    • Higher doses of isoproterenol were needed in older individuals.

    Conclusions:

    • Advancing age is associated with diminished responsiveness of beta-adrenoceptors.
    • This age-related decline affects sensitivity to both beta-agonist and beta-antagonist drugs.
    • Findings suggest potential alterations in cardiovascular drug efficacy in older populations.