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Updated: Aug 4, 2025
05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
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Molecular Profiles of Noninvasive, Minimally Invasive, and Invasive Follicular Patterned Thyroid Neoplasms with
Tamar C Brandler1, Fang Zhou1, Cheng Z Liu1
1Department of Pathology, New York University Langone Health, New York, New York, USA.
Summary
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) share similar genetic profiles, suggesting a continuum. Infiltrative FVPTC shows distinct aggressive molecular drivers, aiding in patient management.
Area of Science:
- Thyroid pathology
- Molecular oncology
- Genomics
Background:
- Follicular patterned thyroid lesions risk-stratified by genetic signatures and morphology.
- RAS-like mutations typically associated with indolent follicular patterned lesions.
- Need to clarify relationship between NIFTP, EFVPTC, and iFVPTC based on molecular profiles.
Purpose of the Study:
- Compare molecular similarity among NIFTP, EFVPTC, and iFVPTC.
- Determine if NIFTP and EFVPTC represent a histological continuum.
- Assess genomic landscape differences in higher-risk follicular patterned tumors.
Main Methods:
- Retrospective study comparing ThyroSeq test results for NIFTP, EFVPTC, and iFVPTC.
- Subcategorized genetic drivers by aggressiveness.
- Compared gene expression alterations (GEAs) and copy number alterations (CNAs) among groups.
Main Results:
- NIFTP and EFVPTC predominantly showed RAS-like alterations and 22q-loss CNAs.
- EFVPTC had more aggressive drivers (22.3%) than NIFTP (0%).
- iFVPTC displayed significantly more aggressive drivers (61.6%) than EFVPTC and NIFTP, indicating higher MAP kinase activity.
Conclusions:
- Follicular patterned lesions with papillary features share RAS-like alterations.
- EFVPTC and NIFTP show molecular overlap, suggesting a genetic continuum.
- Molecular testing can differentiate these tumors, optimizing patient management.
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