Non-coding RNAs regulating mitochondrial function in cardiovascular diseases

Area of Science:

• Biochemistry
• Molecular Biology
• Cardiology

Background:

• Cardiovascular diseases (CVDs) are a leading global cause of death.
• Mitochondrial dysfunction is implicated in CVD pathogenesis, but mechanisms are unclear.
• Non-coding RNAs (ncRNAs) are emerging regulators in cardiovascular health and disease.

Purpose of the Study:

• To review the mechanisms of ncRNA regulation of mitochondrial function in CVD.
• To explore the role of ncRNAs in CVD progression.
• To highlight the clinical potential of ncRNAs as biomarkers and therapeutic targets for CVD.

Main Methods:

• Literature review focusing on ncRNAs, mitochondrial function, and cardiovascular diseases.
• Analysis of studies investigating ncRNA impact on mitochondrial genes and pathways.
• Synthesis of current knowledge on ncRNA clinical applications in CVD.

Main Results:

• ncRNAs, including microRNAs, long non-coding RNAs, and circular RNAs, significantly influence mitochondrial function.
• Dysregulation of specific ncRNAs contributes to the development and progression of various CVDs.
• ncRNAs demonstrate potential as diagnostic/prognostic biomarkers and therapeutic targets for CVD.

Conclusions:

• ncRNAs play critical roles in regulating mitochondrial homeostasis and are key players in CVD.
• Targeting ncRNAs involved in mitochondrial dysfunction presents a promising avenue for CVD treatment.
• Further research into ncRNA mechanisms can accelerate the development of novel CVD therapies.