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BSS Plus: a potential irrigating solution for neurosurgery.

G A Meyer, D J Maiman, H F Edelhauser

    Journal of Neurosurgery
    |June 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    BSS Plus, a pH-stable irrigation solution, better preserved brain tissue than normal saline in neurosurgical simulations. This finding suggests BSS Plus may be a superior choice for neurosurgical procedures.

    Area of Science:

    • Neurosurgery
    • Ophthalmology
    • Biomedical Engineering

    Background:

    • Balanced salt solutions are crucial in surgical irrigation.
    • Glutathione bicarbonate Ringer's solution is a standard, but BSS Plus offers pH stability.
    • Potential applications of BSS Plus extend beyond ophthalmology into neurosurgery.

    Purpose of the Study:

    • To compare the efficacy of BSS Plus versus normal saline for cerebral cortex surface irrigation.
    • To evaluate the impact of these solutions on tissue pH, blood-brain barrier integrity, and tissue preservation.
    • To assess the potential of BSS Plus as an improved neurosurgical irrigation agent.

    Main Methods:

    • Comparative study involving bilateral cerebral cortex irrigation in 28 cats.
    • Assessment of surface pH, blood-brain barrier changes (Evans blue), and evoked potentials.

    Related Experiment Videos

  • Microscopic analysis including light, transmission electron microscopy (TEM), and scanning electron microscopy (SEM).

    • Main Results:

    • BSS Plus maintained surface pH, while normal saline caused a significant decrease.
    • Normal saline irrigation led to more pronounced blood-brain barrier disruption.
    • Electron microscopy revealed superior tissue preservation with BSS Plus compared to normal saline.

    Conclusions:

    • BSS Plus demonstrates superior tissue preservation and pH stability compared to normal saline during cerebral cortex irrigation.
    • The findings suggest BSS Plus is a promising alternative irrigation solution for neurosurgical applications.
    • Further research is warranted to fully establish BSS Plus's role in neurosurgery.