Related Experiment Video
Updated: Aug 4, 2025
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Insight on Serum Albumin: From Structure and Biological Properties to Functional Biomaterials for Bone Repair
Mengmeng Jin1, Songsong Zhu1, Yi Hou1
1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Disease, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Abstract:
Serum albumin (SA), one of the most abundant proteins in blood plasma, plays essential roles in all living processes and has been used in various biomedical applications. Biomaterials fabricated from SAs (human SA, bovine SA, and ovalbumin) exhibit proper microstructure and hydrophilicity as well as remarkable biocompatibility; this makes them ideal for use in bone regeneration. This review provides a comprehensive overview of the structure, physicochemical properties, and biological features of SAs. SAs can be used to generate a wide array of biomaterials for bone repair because of their flexible structure and diverse functions, which enables us to control structure and morphology as well as modulate the biological responses with host tissue. This review summarizes the material categories, forms, and fabrication methods of SA in bone repair. Finally, concerns for future studies in biomedical fields with SA-derived biomaterials are discussed.
Related Concept Videos
01:18The Bone Matrix
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:23Bone as Supporting Connective Tissue
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...