Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lung defense against infection.

P G Quie

    The Journal of Pediatrics
    |May 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    The human lung has robust defenses against bacteria, involving mucus and immune cells like alveolar macrophages. However, cystic fibrosis impairs these defenses, leading to lung infections.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Chronic granulomatous disease and glutathione peroxidase deficiency, revisited.

    Blood·1994
    Same author

    Chronic granulomatous disease of childhood: a saga of discovery and understanding.

    The Pediatric infectious disease journal·1993
    Same author

    Oxidative metabolic products released from polymorphonuclear leukocytes in middle ear fluid during experimental pneumococcal otitis media.

    Infection and immunity·1991
    Same author

    Development of effective programs for control of epidemic streptococcal infections.

    The Pediatric infectious disease journal·1991
    Same author

    Disseminated Candida albicans infection in a patient with Epstein-Barr virus infection.

    Clinical pediatrics·1990
    Same author

    Antimicrobial defenses in the neonate.

    Seminars in perinatology·1990
    Same journal

    Time-to-Transfer and Hospitalization Duration for Severe Congenital Heart Defects: Implications for Perinatal Regionalization.

    The Journal of pediatrics·2026
    Same journal

    Multimodal neuromonitoring in neonatal hypoxic-ischemic encephalopathy and the association with neurodevelopmental outcomes: A Multicenter Study.

    The Journal of pediatrics·2026
    Same journal

    KP.2-Adapted BNT162b2 COVID-19 Vaccine Uptake and Effectiveness in Children.

    The Journal of pediatrics·2026
    Same journal

    Respiratory Syncytial Virus Immunization Disparities in Mothers and Infants at the Birth Hospitalization: A Cross-Sectional Study.

    The Journal of pediatrics·2026
    Same journal

    Blood-Based Biomarkers Predict Cerebral Palsy and Cognitive Delay in Hypoxic-Ischemic Encephalopathy: A Secondary Analysis of the HEAL Randomized Controlled Trial.

    The Journal of pediatrics·2026
    Same journal

    Does Mild Head Injury in Childhood Affect Later School Performance? A Sibling Comparison Cohort Study.

    The Journal of pediatrics·2026
    See all related articles

    Area of Science:

    • Pulmonary immunology
    • Infectious disease

    Background:

    • The human lung possesses a complex defense system against microbial invasion.
    • Key components include mucus, the mucus-ciliary escalator, and the pulmonary phagocytic system.

    Purpose of the Study:

    • To elucidate the mechanisms of normal lung defense against bacterial pathogens.
    • To identify defects in lung defense mechanisms in patients with cystic fibrosis.
    • To inform the development of strategies for combating microbial infections in cystic fibrosis.

    Main Methods:

    • Review of existing literature on lung immunity and host-pathogen interactions.
    • Analysis of the roles of mucus, alveolar macrophages, granulocytes, and humoral factors.

    Main Results:

    Related Experiment Videos

    • Normal lungs maintain sterility through effective physical barriers and potent bactericidal mechanisms.
    • Alveolar macrophages and granulocytes utilize oxidative and nonoxidative pathways to kill microbes.
    • Certain pathogens evade phagocytosis or survive intracellularly.

    Conclusions:

    • The normal lung's defense systems are highly effective against most common microbes.
    • Cystic fibrosis disrupts these defenses, allowing bacterial colonization and lung damage.
    • Understanding these defense mechanisms is crucial for developing new therapies for cystic fibrosis patients.